Four months on semaglutide. Down 30 lbs. But here’s what caught me off guard — my anxiety dropped noticeably, and my overall mood got better too.
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Turns out there’s real research emerging on GLP-1 drugs affecting the brain, not just metabolism. Anyone else notice mental health shifts on GLP-1 medications?
You’re not imagining it.
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Yes! I’m on tirzepatide and noticed the same thing. Less anxiety, more motivation, better sleep. My doctor said it could be partly from the weight loss improving sleep apnea and inflammation.
I had the opposite experience unfortunately. Semaglutide made me feel foggy and kind of flat emotionally for the first two months. It got better after that but wanted to share.
The neuroscience behind this is fascinating. GLP-1 receptors exist throughout the brain, not just in areas related to appetite. There was a Lancet study showing potential neuroprotective effects.
down 45 lbs on ozempic and the mood improvement was the biggest surprise. sleeping better, less brain fog, way less stress eating obviously